We examined how rodent activity influenced the fates of seeds of two palm species (Astrocaryum standleyanum L.H. Bailey and Attalea butyracea (Mutis ex L.f.) Wess. Boer). Intact fruits were placed in exclosures at three heights (ground understory and canopy) and removed seeds were tracked with attached sewing bobbins. We recorded 50 handling events. Most seeds were discarded after removal and the fruit eaten and only one seed was cached in the ground. Fruit and seed handling activity showed strong associations with lianas indicating that changes in liana abundance resulting from human activity could greatly influence seed fate and therefore affect forest regeneration and potentially impact local biodiversity.